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fapi 46 precursor  (MedChemExpress)


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    Structured Review

    MedChemExpress fapi 46 precursor
    Representative chemical structures and functional groups of (A) FAPI-04, (B) <t>FAPI-46,</t> and (C) Alb-FAPtp-01 and (D) the developed peptide tracer (Alb-FAPtp-02). (E) FAP expression level in U-87MG and HEK293T. (F) Cellular uptake of ⁶⁸Ga-FAPI-04, ⁶⁸Ga-FAPI-46, and ⁶⁸Ga-Alb-FAPtp-02 in U-87 MG and HEK293T cells. No significant. (G) Competitive binding assay showing inhibition of tracer uptake in U-87 MG cells by non-radiolabeled FAPI-04, confirming FAP-specific binding (n = 3, mean ± s.d.). ( H ) In vivo dynamic PET imaging analysis comparison of FAP tracers. Representative dynamic PET/CT imaging of ⁶⁸Ga-Alb-FAPtp-02, ⁶⁸Ga-FAPI-46 and ⁶⁸Ga-FAPI-04 in mice with glioma xenografts. (I) the corresponding time-activity curves of radiotracers for U-87 MG tumors and muscle. Statistical significance was determined using one-way ANOVA followed by Tukey's HSD post hoc test. * p < 0.05.
    Fapi 46 Precursor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/fapi 46 precursor/product/MedChemExpress
    Average 94 stars, based on 7 article reviews
    fapi 46 precursor - by Bioz Stars, 2026-03
    94/100 stars

    Images

    1) Product Images from "Engineering a modular FAP-targeting ferritin-based drug nanocarrier for enhanced glioblastoma theranostics"

    Article Title: Engineering a modular FAP-targeting ferritin-based drug nanocarrier for enhanced glioblastoma theranostics

    Journal: Theranostics

    doi: 10.7150/thno.125403

    Representative chemical structures and functional groups of (A) FAPI-04, (B) FAPI-46, and (C) Alb-FAPtp-01 and (D) the developed peptide tracer (Alb-FAPtp-02). (E) FAP expression level in U-87MG and HEK293T. (F) Cellular uptake of ⁶⁸Ga-FAPI-04, ⁶⁸Ga-FAPI-46, and ⁶⁸Ga-Alb-FAPtp-02 in U-87 MG and HEK293T cells. No significant. (G) Competitive binding assay showing inhibition of tracer uptake in U-87 MG cells by non-radiolabeled FAPI-04, confirming FAP-specific binding (n = 3, mean ± s.d.). ( H ) In vivo dynamic PET imaging analysis comparison of FAP tracers. Representative dynamic PET/CT imaging of ⁶⁸Ga-Alb-FAPtp-02, ⁶⁸Ga-FAPI-46 and ⁶⁸Ga-FAPI-04 in mice with glioma xenografts. (I) the corresponding time-activity curves of radiotracers for U-87 MG tumors and muscle. Statistical significance was determined using one-way ANOVA followed by Tukey's HSD post hoc test. * p < 0.05.
    Figure Legend Snippet: Representative chemical structures and functional groups of (A) FAPI-04, (B) FAPI-46, and (C) Alb-FAPtp-01 and (D) the developed peptide tracer (Alb-FAPtp-02). (E) FAP expression level in U-87MG and HEK293T. (F) Cellular uptake of ⁶⁸Ga-FAPI-04, ⁶⁸Ga-FAPI-46, and ⁶⁸Ga-Alb-FAPtp-02 in U-87 MG and HEK293T cells. No significant. (G) Competitive binding assay showing inhibition of tracer uptake in U-87 MG cells by non-radiolabeled FAPI-04, confirming FAP-specific binding (n = 3, mean ± s.d.). ( H ) In vivo dynamic PET imaging analysis comparison of FAP tracers. Representative dynamic PET/CT imaging of ⁶⁸Ga-Alb-FAPtp-02, ⁶⁸Ga-FAPI-46 and ⁶⁸Ga-FAPI-04 in mice with glioma xenografts. (I) the corresponding time-activity curves of radiotracers for U-87 MG tumors and muscle. Statistical significance was determined using one-way ANOVA followed by Tukey's HSD post hoc test. * p < 0.05.

    Techniques Used: Functional Assay, Expressing, Competitive Binding Assay, Inhibition, Binding Assay, In Vivo, Imaging, Comparison, Positron Emission Tomography-Computed Tomography, Activity Assay



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    fapi 46 precursor  (MedChemExpress)
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    Representative chemical structures and functional groups of (A) FAPI-04, (B) <t>FAPI-46,</t> and (C) Alb-FAPtp-01 and (D) the developed peptide tracer (Alb-FAPtp-02). (E) FAP expression level in U-87MG and HEK293T. (F) Cellular uptake of ⁶⁸Ga-FAPI-04, ⁶⁸Ga-FAPI-46, and ⁶⁸Ga-Alb-FAPtp-02 in U-87 MG and HEK293T cells. No significant. (G) Competitive binding assay showing inhibition of tracer uptake in U-87 MG cells by non-radiolabeled FAPI-04, confirming FAP-specific binding (n = 3, mean ± s.d.). ( H ) In vivo dynamic PET imaging analysis comparison of FAP tracers. Representative dynamic PET/CT imaging of ⁶⁸Ga-Alb-FAPtp-02, ⁶⁸Ga-FAPI-46 and ⁶⁸Ga-FAPI-04 in mice with glioma xenografts. (I) the corresponding time-activity curves of radiotracers for U-87 MG tumors and muscle. Statistical significance was determined using one-way ANOVA followed by Tukey's HSD post hoc test. * p < 0.05.
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    Representative chemical structures and functional groups of (A) FAPI-04, (B) <t>FAPI-46,</t> and (C) Alb-FAPtp-01 and (D) the developed peptide tracer (Alb-FAPtp-02). (E) FAP expression level in U-87MG and HEK293T. (F) Cellular uptake of ⁶⁸Ga-FAPI-04, ⁶⁸Ga-FAPI-46, and ⁶⁸Ga-Alb-FAPtp-02 in U-87 MG and HEK293T cells. No significant. (G) Competitive binding assay showing inhibition of tracer uptake in U-87 MG cells by non-radiolabeled FAPI-04, confirming FAP-specific binding (n = 3, mean ± s.d.). ( H ) In vivo dynamic PET imaging analysis comparison of FAP tracers. Representative dynamic PET/CT imaging of ⁶⁸Ga-Alb-FAPtp-02, ⁶⁸Ga-FAPI-46 and ⁶⁸Ga-FAPI-04 in mice with glioma xenografts. (I) the corresponding time-activity curves of radiotracers for U-87 MG tumors and muscle. Statistical significance was determined using one-way ANOVA followed by Tukey's HSD post hoc test. * p < 0.05.
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    Representative chemical structures and functional groups of (A) FAPI-04, (B) <t>FAPI-46,</t> and (C) Alb-FAPtp-01 and (D) the developed peptide tracer (Alb-FAPtp-02). (E) FAP expression level in U-87MG and HEK293T. (F) Cellular uptake of ⁶⁸Ga-FAPI-04, ⁶⁸Ga-FAPI-46, and ⁶⁸Ga-Alb-FAPtp-02 in U-87 MG and HEK293T cells. No significant. (G) Competitive binding assay showing inhibition of tracer uptake in U-87 MG cells by non-radiolabeled FAPI-04, confirming FAP-specific binding (n = 3, mean ± s.d.). ( H ) In vivo dynamic PET imaging analysis comparison of FAP tracers. Representative dynamic PET/CT imaging of ⁶⁸Ga-Alb-FAPtp-02, ⁶⁸Ga-FAPI-46 and ⁶⁸Ga-FAPI-04 in mice with glioma xenografts. (I) the corresponding time-activity curves of radiotracers for U-87 MG tumors and muscle. Statistical significance was determined using one-way ANOVA followed by Tukey's HSD post hoc test. * p < 0.05.
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    Representative chemical structures and functional groups of (A) FAPI-04, (B) <t>FAPI-46,</t> and (C) Alb-FAPtp-01 and (D) the developed peptide tracer (Alb-FAPtp-02). (E) FAP expression level in U-87MG and HEK293T. (F) Cellular uptake of ⁶⁸Ga-FAPI-04, ⁶⁸Ga-FAPI-46, and ⁶⁸Ga-Alb-FAPtp-02 in U-87 MG and HEK293T cells. No significant. (G) Competitive binding assay showing inhibition of tracer uptake in U-87 MG cells by non-radiolabeled FAPI-04, confirming FAP-specific binding (n = 3, mean ± s.d.). ( H ) In vivo dynamic PET imaging analysis comparison of FAP tracers. Representative dynamic PET/CT imaging of ⁶⁸Ga-Alb-FAPtp-02, ⁶⁸Ga-FAPI-46 and ⁶⁸Ga-FAPI-04 in mice with glioma xenografts. (I) the corresponding time-activity curves of radiotracers for U-87 MG tumors and muscle. Statistical significance was determined using one-way ANOVA followed by Tukey's HSD post hoc test. * p < 0.05.
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    Representative chemical structures and functional groups of (A) FAPI-04, (B) <t>FAPI-46,</t> and (C) Alb-FAPtp-01 and (D) the developed peptide tracer (Alb-FAPtp-02). (E) FAP expression level in U-87MG and HEK293T. (F) Cellular uptake of ⁶⁸Ga-FAPI-04, ⁶⁸Ga-FAPI-46, and ⁶⁸Ga-Alb-FAPtp-02 in U-87 MG and HEK293T cells. No significant. (G) Competitive binding assay showing inhibition of tracer uptake in U-87 MG cells by non-radiolabeled FAPI-04, confirming FAP-specific binding (n = 3, mean ± s.d.). ( H ) In vivo dynamic PET imaging analysis comparison of FAP tracers. Representative dynamic PET/CT imaging of ⁶⁸Ga-Alb-FAPtp-02, ⁶⁸Ga-FAPI-46 and ⁶⁸Ga-FAPI-04 in mice with glioma xenografts. (I) the corresponding time-activity curves of radiotracers for U-87 MG tumors and muscle. Statistical significance was determined using one-way ANOVA followed by Tukey's HSD post hoc test. * p < 0.05.
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    Image Search Results


    Representative chemical structures and functional groups of (A) FAPI-04, (B) FAPI-46, and (C) Alb-FAPtp-01 and (D) the developed peptide tracer (Alb-FAPtp-02). (E) FAP expression level in U-87MG and HEK293T. (F) Cellular uptake of ⁶⁸Ga-FAPI-04, ⁶⁸Ga-FAPI-46, and ⁶⁸Ga-Alb-FAPtp-02 in U-87 MG and HEK293T cells. No significant. (G) Competitive binding assay showing inhibition of tracer uptake in U-87 MG cells by non-radiolabeled FAPI-04, confirming FAP-specific binding (n = 3, mean ± s.d.). ( H ) In vivo dynamic PET imaging analysis comparison of FAP tracers. Representative dynamic PET/CT imaging of ⁶⁸Ga-Alb-FAPtp-02, ⁶⁸Ga-FAPI-46 and ⁶⁸Ga-FAPI-04 in mice with glioma xenografts. (I) the corresponding time-activity curves of radiotracers for U-87 MG tumors and muscle. Statistical significance was determined using one-way ANOVA followed by Tukey's HSD post hoc test. * p < 0.05.

    Journal: Theranostics

    Article Title: Engineering a modular FAP-targeting ferritin-based drug nanocarrier for enhanced glioblastoma theranostics

    doi: 10.7150/thno.125403

    Figure Lengend Snippet: Representative chemical structures and functional groups of (A) FAPI-04, (B) FAPI-46, and (C) Alb-FAPtp-01 and (D) the developed peptide tracer (Alb-FAPtp-02). (E) FAP expression level in U-87MG and HEK293T. (F) Cellular uptake of ⁶⁸Ga-FAPI-04, ⁶⁸Ga-FAPI-46, and ⁶⁸Ga-Alb-FAPtp-02 in U-87 MG and HEK293T cells. No significant. (G) Competitive binding assay showing inhibition of tracer uptake in U-87 MG cells by non-radiolabeled FAPI-04, confirming FAP-specific binding (n = 3, mean ± s.d.). ( H ) In vivo dynamic PET imaging analysis comparison of FAP tracers. Representative dynamic PET/CT imaging of ⁶⁸Ga-Alb-FAPtp-02, ⁶⁸Ga-FAPI-46 and ⁶⁸Ga-FAPI-04 in mice with glioma xenografts. (I) the corresponding time-activity curves of radiotracers for U-87 MG tumors and muscle. Statistical significance was determined using one-way ANOVA followed by Tukey's HSD post hoc test. * p < 0.05.

    Article Snippet: The FAPI-04 precursor was sourced from KriSan Biotech Co. (Tainan, Taiwan), a PICS/GMP-compliant pharmaceutical manufacturer, whereas the FAPI-46 precursor was purchased from MedChemExpress (MCE, New Jersey, USA).

    Techniques: Functional Assay, Expressing, Competitive Binding Assay, Inhibition, Binding Assay, In Vivo, Imaging, Comparison, Positron Emission Tomography-Computed Tomography, Activity Assay